Insulin-dependent Synthesis of Liver Glucokinase in the Rat
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Insulin-dependent Synthesis of Liver Glucokinase in the Rat.
A glucokinase qualitatively and quantitatively adequate as the first and limiting step in the synthesis of glycogen from glucose has been recently identified in the liver of the normal fed rat. In contrast with hexokinase, glucokinase activity was found to disappear in fasted and alloxan-diabetic animals (1). A characteristic shared by deprivation of food and diabetes is the marked decrease of ...
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15 صفحه اولInhibition by catecholamines of the induction of rat liver glucokinase.
Epinephrine, norepinephrine, and isoproterenol prevent the induction of rat liver glucokinase (EC 2.7.1.2) produced by the administration of glucose to animals with low levels of the enzyme. The low levels of glucokinase were obtained by feeding the animals a carbohydrate-free diet for 6 days. When epinepbrine was given 4 hours after the administration of carbohydrate there was only a slight in...
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Several lines of evidence suggest a strong genetic component to NIDDM. To clarify the role of glucokinase gene in the development of NIDDM, restriction fragment length polymorphism (RFLP) of glucokinase gene and 3' microsatellite polymorphism analyses by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) were performed in NIDDM and control subjects. Compared to NIDDM...
متن کاملAlternative splicing of glucokinase mRNA in rat liver.
The sequences of two near full-length cDNAs encoding rat liver glucokinase are reported. One of the cDNAs is essentially identical to the cDNA cloned by Andreone, Printz, Pilkis, Magnuson & Granner. [(1989) J. Biol. Chem. 264, 363-369]. The other cDNA contains a 151 bp insertion and a downstream 52 bp deletion. The inserted block of bases has been shown to originate from an optional cassette ex...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1963
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)75303-4